Cancer in Inflammatory Bowel Disease

Gastroenterol Clin North Am. 2022 Sep;51(3):649-666. doi: 10.1016/j.gtc.2022.05.003. Epub 2022 Aug 30.


Inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, are chronic inflammatory conditions of the gastrointestinal tract. Individuals with IBD are at increased risk for several malignancies originating in the intestine, such as colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, and anal cancer. There are also several extraintestinal malignancies associated with IBD and IBD therapies, including cholangiocarcinoma, skin cancer, hematologic malignancies, genitourinary cancer, cervical cancer, and prostate cancer. The authors summarize the risk of cancer in patients with IBD, diagnosis and management of colorectal neoplasia in IBD, and management of patients with IBD and active or recent cancer.

Keywords: Cancer; Colorectal neoplasia; Crohn disease; Dysplasia; Inflammatory bowel disease; Ulcerative colitis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chronic Disease
  • Colitis, Ulcerative* / diagnosis
  • Colorectal Neoplasms* / diagnosis
  • Colorectal Neoplasms* / epidemiology
  • Colorectal Neoplasms* / etiology
  • Crohn Disease* / complications
  • Crohn Disease* / therapy
  • Humans
  • Inflammatory Bowel Diseases* / complications
  • Inflammatory Bowel Diseases* / therapy
  • Lymphoma* / diagnosis
  • Lymphoma* / etiology
  • Lymphoma* / therapy
  • Male