Will Peptides Help to Stop COVID-19?

Biochemistry (Mosc). 2022 Jul;87(7):590-604. doi: 10.1134/S0006297922070021.


Peptides are widely used for the diagnostics, prevention, and therapy of certain human diseases. How useful can they be for the disease caused by the SARS-CoV-2 coronavirus? In this review, we discuss the possibility of using synthetic and recombinant peptides and polypeptides for prevention of COVID-19 via blocking the interaction between the virus and its main receptor ACE2, as well as components of antiviral vaccines, in particular, against new emerging virus variants.

Keywords: ACE2; SARS-CoV-2; T-cell epitopes; vaccine.

Publication types

  • Review

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Antiviral Agents / therapeutic use
  • COVID-19*
  • Humans
  • Peptides / therapeutic use
  • SARS-CoV-2


  • Antiviral Agents
  • Peptides
  • Angiotensin-Converting Enzyme 2