Identifying barriers to compliance with a universal inpatient protocol for Staphylococcus aureus nasal decolonization with povidone-iodine

Infect Control Hosp Epidemiol. 2023 Jul;44(7):1167-1170. doi: 10.1017/ice.2022.234. Epub 2022 Sep 26.


Academic hospital nurses were surveyed to assess adherence barriers to a universal povidone-iodine nasal decolonization protocol to prevent Staphylococcus aureus infection. Low training rates, inadequate supplies, documentation and tracking challenges, patient refusal, and burnout contributed to suboptimal adherence. Prioritizing education is essential but alone is insufficient for successful protocol adoption.

MeSH terms

  • Anti-Bacterial Agents
  • Carrier State
  • Humans
  • Inpatients
  • Methicillin-Resistant Staphylococcus aureus*
  • Mupirocin
  • Nose
  • Povidone-Iodine / therapeutic use
  • Staphylococcal Infections* / drug therapy
  • Staphylococcal Infections* / prevention & control
  • Staphylococcus aureus


  • Povidone-Iodine
  • Anti-Bacterial Agents
  • Mupirocin