The Effect of a Citrus and Pomegranate Complex on Physical Fitness and Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled Trial

J Nutr Health Aging. 2022;26(9):839-846. doi: 10.1007/s12603-022-1834-4.


Objectives: This study investigates whether a citrus and pomegranate complex (CPC) improves physical fitness, mental well-being, and blood biomarkers for oxidative stress and endothelial function in healthy elderly.

Design: A randomized placebo-controlled cross-over trial.

Participants: The study included 36 healthy elderly aged 60-75 years old.

Intervention and measurements: Participants received four weeks of CPC supplementation and performed the handgrip strength and senior fitness test. Quality of life (QOL) was assessed and blood samples were analyzed for oxidative stress and endothelial function markers.

Results: After four weeks of CPC supplementation, handgrip strength significantly improved (p=0.019), compared to placebo. Moreover, the thinking, memory, learning, and concentration facets were improved (p=0.042), compared to placebo, and plasma malondialdehyde decreased, compared to placebo (p=0.033). The intervention did not affect senior fitness and the other QOL domains and blood parameters.

Conclusion: Four weeks of daily CPC supplementation significantly improves handgrip strength and self-evaluated measures of psychological function in healthy older adults. Further research should focus on mechanisms associated with physical performance.

Keywords: Citrus fruit; hesperidin; physical fitness; polyphenols; quality of life.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers
  • Citrus*
  • Dietary Supplements
  • Double-Blind Method
  • Hand Strength
  • Humans
  • Malondialdehyde
  • Physical Fitness
  • Pomegranate*
  • Quality of Life


  • Biomarkers
  • Malondialdehyde