The complement system and autoimmune diseases

Chronic Dis Transl Med. 2022 Apr 6;8(3):184-190. doi: 10.1002/cdt3.24. eCollection 2022 Sep.


The complement system plays a key role in the pathogenesis of autoimmune diseases, which usually injures the kidney. More and more studies have shown the pathogenic role and indicated that abnormal activation of the complement system was highly involved in the outbreak of autoimmune diseases. This review mainly introduced recent studies of complement system activation contributing to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, antiphospholipid syndrome, antineutrophil cytoplasmic antibody-associated vasculitides, and so on. Understanding the pathogenic roles of complement activation in various autoimmune diseases will identify potential novel therapeutic targets on complement systems.

Keywords: ANCA‐associated vasculitides; antiphospholipid syndrome; autoimmune disease; complement; systemic lupus erythematosus.

Publication types

  • Review