Proton Pump Inhibitors in Allergy: Benefits and Risks

J Allergy Clin Immunol Pract. 2022 Dec;10(12):3117-3123. doi: 10.1016/j.jaip.2022.09.022. Epub 2022 Sep 23.

Abstract

Proton pump inhibitors (PPIs) are widely prescribed and are indicated for the treatment of several gastrointestinal disorders. Allergists may prescribe PPIs as a result of the coincidence of gastroesophageal reflux disease with asthma or rhinitis, or when gastroesophageal reflux disease presents as chronic cough. Furthermore, long-term, high-dose PPI therapy is a recommended option for managing eosinophilic esophagitis, resulting in histologic remission in approximately 40% of patients. Here, we discuss current recommendations for PPI use, its deescalation, and its side effect profile. We review evidence supporting the epidemiologic link between the use of acid-suppressant medication and the subsequent development of allergic disorders.

Keywords: Adverse events; Asthma; Eosinophilic esophagitis; Hypersensitivity; Proton pump inhibitor.

Publication types

  • Review

MeSH terms

  • Asthma* / chemically induced
  • Asthma* / drug therapy
  • Asthma* / epidemiology
  • Eosinophilic Esophagitis* / chemically induced
  • Eosinophilic Esophagitis* / drug therapy
  • Eosinophilic Esophagitis* / epidemiology
  • Gastritis* / drug therapy
  • Gastroesophageal Reflux* / drug therapy
  • Gastroesophageal Reflux* / epidemiology
  • Humans
  • Proton Pump Inhibitors

Substances

  • Proton Pump Inhibitors