Right Heart Function in Cardiorenal Syndrome

Curr Heart Fail Rep. 2022 Dec;19(6):386-399. doi: 10.1007/s11897-022-00574-x. Epub 2022 Sep 27.

Abstract

Purpose of review: Since CRS is critically dependent on right heart function and involved in interorgan crosstalk, assessment and monitoring of both right heart and kidney function are of utmost importance for clinical outcomes. This systematic review aims to comprehensively report on novel diagnostic and therapeutic paradigms that are gaining importance for the clinical management of the growing heart failure population suffering from CRS.

Recent findings: Cardiorenal syndrome (CRS) in patients with heart failure is associated with poor outcome. Although systemic venous congestion and elevated central venous pressure have been recognized as main contributors to CRS, they are often neglected in clinical practice. The delicate hemodynamic balance in CRS is particularly determined by the respective status of the right heart. The consideration of hemodynamic and CRS profiles is advantageous in tailoring treatment for better preservation of renal function. Assessment and monitoring of right heart and renal function by known and emerging tools like renal Doppler ultrasonography or new biomarkers may have direct clinical implications.

Keywords: Biomarkers; Cardiorenal syndrome; Pulmonary arterial hypertension; Pulmonary hypertension; Renal dysfunction; Right heart failure; Right heart function; Treatment approaches; Venous congestion.

Publication types

  • Systematic Review
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • Cardio-Renal Syndrome*
  • Heart Failure*
  • Hemodynamics
  • Humans

Substances

  • Biomarkers