Recent two-year advances in anti-dengue small-molecule inhibitors

Chao Yang; Wansheng Xie; Heqian Zhang; Wenjian Xie; Tiantian Tian; Zhiwei Qin

doi:10.1016/j.ejmech.2022.114753

Recent two-year advances in anti-dengue small-molecule inhibitors

Eur J Med Chem. 2022 Dec 5:243:114753. doi: 10.1016/j.ejmech.2022.114753. Epub 2022 Sep 22.

Authors

Chao Yang¹, Wansheng Xie², Heqian Zhang³, Wenjian Xie⁴, Tiantian Tian⁵, Zhiwei Qin⁶

Affiliations

¹ State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macao University of Science and Technology, Macao, 999078, China.
² Hainan Center for Drug and Medical Device Evaluation and Service, Hainan Provincial Drug Administration, Haikou, Hainan, 570206, China.
³ Center for Biological Science and Technology, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai, Guangdong, 519087, China.
⁴ School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, PR China.
⁵ Center for Biological Science and Technology, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai, Guangdong, 519087, China. Electronic address: t.tian@bnu.edu.cn.
⁶ Center for Biological Science and Technology, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai, Guangdong, 519087, China. Electronic address: z.qin@bnu.edu.cn.

PMID: 36167010
DOI: 10.1016/j.ejmech.2022.114753

Abstract

Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years.

Keywords: Aedes aegypti; Dengue fever; Flaviviruses; Inhibitors; Tropical diseases.

MeSH terms

Aedes*
Animals
Dengue Virus*