Ceftriaxone for treatment of primary syphilis in men: a preliminary study

Sex Transm Dis. 1987 Apr-Jun;14(2):116-8. doi: 10.1097/00007435-198704000-00013.


Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection). The single 3-g dose of ceftriaxone cured three men, one had a sustained response, and one failed to be cured. Of the patients given 2 g of ceftriaxone im daily for two days, three were cured and two had a sustained response. All three men treated with 2 g of ceftriaxone daily for five days had a sustained response. In the group given penicillin, three men were cured, one had a sustained response, and one was lost to follow-up.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Ceftriaxone / administration & dosage
  • Ceftriaxone / therapeutic use*
  • Drug Administration Schedule
  • Humans
  • Male
  • Middle Aged
  • Penicillin G Benzathine / therapeutic use
  • Prospective Studies
  • Random Allocation
  • Syphilis / drug therapy*


  • Ceftriaxone
  • Penicillin G Benzathine