Multiple Epstein-Barr Virus-associated Gastric Cancers Arising in a Patient with Autoimmune Gastritis

Intern Med. 2023 May 15;62(10):1459-1466. doi: 10.2169/internalmedicine.0673-22. Epub 2022 Sep 28.


Epstein-Barr virus-associated gastric cancer (EBVaGC) has been reported to be associated with chronic inflammation of the gastric epithelium caused by Helicobacter pylori infection. Autoimmune gastritis (AIG) is also believed to increase the risk of carcinogenesis. We herein report a case of multiple EBVaGCs that arose in a patient with AIG, highlighting the potential for multiplicity of this entity. In this case, a total of four metachronous EBVaGCs were found after initial Endoscopic submucosal dissection for EBVaGC, all of which were treated endoscopically. This case demonstrates that patients with AIG should be monitored closely for development of EBVaGC.

Keywords: Epstein-Barr virus; endoscopic submucosal dissection; gastric cancer.

Publication types

  • Case Reports

MeSH terms

  • Epstein-Barr Virus Infections* / complications
  • Gastritis* / complications
  • Helicobacter Infections* / complications
  • Helicobacter pylori*
  • Herpesvirus 4, Human
  • Humans
  • Stomach Neoplasms* / complications
  • Stomach Neoplasms* / surgery