Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination

Ankoor H Patel; Rajan Amin; Alexander T Lalos

doi:10.14744/hf.2022.2022.0019

Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination

Hepatol Forum. 2022 Sep 23;3(3):97-99. doi: 10.14744/hf.2022.2022.0019. eCollection 2022 Sep.

Authors

Ankoor H Patel¹, Rajan Amin¹, Alexander T Lalos¹

Affiliation

¹ Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Abstract

IgG4-related disease (IgG4-RD) is a fibro-inflammatory disease that can affect multiple organs. Autoimmune pancreatitis type 1 is a manifestation of IgG4-RD and can often mimic tumor-like masses. Autoimmune phenomena following COVID-19 mRNA vaccination are being increasingly reported. Currently, there are no cases in which IgG4-RD involving the hepatobiliary system has been reported following the COVID-19 vaccination. We present the first case of IgG4-RD and AIP type 1 to be associated with the mRNA-based COVID-19 vaccination.

Keywords: Autoimmune pancreatitis; COVID-19; IgG4; mRNA vaccine.

Publication types

Case Reports