Acid fibroblast growth factor (aFGF) is a member of fibroblast growth factors (FGF) family, widely promoting embryonic development, wound healing, vascular regeneration, nerve injury repair, as well as regulating immune metabolism. Many pathophysiological processes, such as inflammation, neovascularization, proliferation and migration of repair cells, and deposition of collagen and other extracellular matrix are involved in the process of wound healing. Based on the relevant literature in recent years, this article mainly reviews the research progresses on the roles and mechanism of aFGF in biological signal transduction, regulation of cell growth, and involvement in tissue repair, and discusses the current research hot spots as well as the prospective future direction of clinical applications of aFGF in the aspect of clinical pharmacokinetics and safety.
酸性成纤维细胞生长因子（aFGF）是成纤维细胞生长因子（FGF）家族成员之一，具有广泛地促进胚胎发育、创面愈合、血管再生、神经损伤修复，以及调控免疫代谢的作用。创面愈合包含了炎症反应、新生血管形成、修复细胞的增殖与迁移、胶原等ECM的沉积等病理生理过程。该文在查阅近年来相关文献的基础上，围绕aFGF在传导生物信号、调节细胞生长、参与组织修复中的作用及相关机制研究进展进行综述，并从临床药代动力学和安全性角度，对aFGF的当前研究热点和未来临床应用方向进行展望。.