Dissecting the intracellular pancreatic tumor microbiome at single-cell level

Thomas S B Schmidt; Peer Bork

doi:10.1016/j.ccell.2022.09.005

Dissecting the intracellular pancreatic tumor microbiome at single-cell level

Cancer Cell. 2022 Oct 10;40(10):1083-1085. doi: 10.1016/j.ccell.2022.09.005. Epub 2022 Sep 29.

Authors

Thomas S B Schmidt¹, Peer Bork²

Affiliations

¹ Structural & Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. Electronic address: sebastian.schmidt@embl.de.
² Structural & Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Yonsei Frontier Lab (YFL), Yonsei University, Seoul 03722, South Korea; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. Electronic address: peer.bork@embl.org.

PMID: 36179685
DOI: 10.1016/j.ccell.2022.09.005

Abstract

Microorganisms play a role in the progression of various cancers. In this issue of Cancer Cell, Ghaddar et al. traced bacteria in pancreatic tumors at single-cell resolution and associated their intracellular presence with cell-type-specific transcriptional shifts, with links to clinical prognosis.

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MeSH terms

Bacteria / genetics
Humans
Microbiota*
Pancreatic Neoplasms* / genetics
Pancreatic Neoplasms* / pathology
Prognosis