Semiconducting metal-organic framework derivatives-gated organic photoelectrochemical transistor immunoassay

Cheng-Jun Li; Yi-Tong Xu; Meng-Jiao Lu; Yu-Mei Li; Rui Ban; Jin Hu; Ge Gao; Xiao-Ya Dong; Hong Zhou; Peng Lin; Wei-Wei Zhao

doi:10.1016/j.bios.2022.114700

Semiconducting metal-organic framework derivatives-gated organic photoelectrochemical transistor immunoassay

Biosens Bioelectron. 2022 Dec 1:217:114700. doi: 10.1016/j.bios.2022.114700. Epub 2022 Sep 16.

Authors

Cheng-Jun Li¹, Yi-Tong Xu², Meng-Jiao Lu¹, Yu-Mei Li³, Rui Ban⁴, Jin Hu⁵, Ge Gao², Xiao-Ya Dong⁶, Hong Zhou⁷, Peng Lin⁸, Wei-Wei Zhao⁹

Affiliations

¹ School of Chemical Engineering, Guizhou Minzu University, Guiyang, 550025, China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
² State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
³ School of Chemical Engineering, Guizhou Minzu University, Guiyang, 550025, China. Electronic address: gzmd_lym@163.com.
⁴ School of Chemical Engineering, Guizhou Minzu University, Guiyang, 550025, China; School of Chemistry and Materials Science, Guizhou Education University, Guiyang, 550018, China. Electronic address: Banrui@gznc.edu.cn.
⁵ State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China; Shenzhen Key Laboratory of Special Functional Materials & Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
⁶ The Key Laboratory of Modern Agricultural Equipment and Technology (MOE), The Key Laboratory of Plant Protection Engineering, School of Agricultural Eqipmental Engineering, Jiangsu University, Zhenjiang, 212013, China. Electronic address: dongxiaoya@ujs.edu.cn.
⁷ Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
⁸ Shenzhen Key Laboratory of Special Functional Materials & Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
⁹ State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. Electronic address: zww@nju.edu.cn.

PMID: 36182837
DOI: 10.1016/j.bios.2022.114700

Abstract

Metal-organic framework (MOF) derivatives with unique physicochemical and electronic properties have seen a tremendous growth in diverse applications. Organic optobioelectronics have long been pursued in modern electronics for next-generation bio-relevant implementations. The intersection of these two disciplines could be an appealing way to pursue better performance of materials and devices. Herein this work reports the exploration of MOF derivatives and its ionic modulation for gating organic photoelectrochemical transistor (OPECT) biosensing. In the representative system of poly(ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) gated by zeolitic-imidazolate-framework (ZIF)-8-derived Cd_xZn_1-xS, a high current gain could be achieved at zero gate bias. In connection to a CuO nanoparticle-labeled sandwich immunoassay, acidolysis-triggered Cu²⁺-induced ionic modulation of the system results into a good performance toward human IgG with a low limit of detection of 0.003 pg/mL. This work features the MOF derivative-gated organic electronics and is expected to inspire more interest to explore various MOF derivative electronics with unknown possibilities, considering the diversity of MOF derivatives.

Keywords: Derivatives; Immunoassay; Ionic gating; Metal-organic frameworks; Organic photoelectrochemical transistors.

MeSH terms

Biosensing Techniques* / methods
Cadmium
Humans
Immunoassay
Immunoglobulin G
Ions
Metal-Organic Frameworks* / chemistry
Styrenes

Substances

Immunoglobulin G
Ions
Metal-Organic Frameworks
Styrenes
Cadmium