Connectivity of the corticostriatal and thalamostriatal systems in normal and parkinsonian states: An update

Neurobiol Dis. 2022 Nov:174:105878. doi: 10.1016/j.nbd.2022.105878. Epub 2022 Sep 29.


The striatum receives abundant glutamatergic afferents from the cortex and thalamus. These inputs play a major role in the functions of the striatal neurons in normal conditions, and are significantly altered in pathological states, such as Parkinson's disease. This review summarizes the current knowledge of the connectivity of the corticostriatal and thalamostriatal pathways, with emphasis on the most recent advances in the field. We also discuss novel findings regarding structural changes in cortico- and thalamostriatal connections that occur in these connections as a consequence of striatal loss of dopamine in parkinsonism.

Keywords: Cortex; Parkinsonism; Striatal neurons; Striatum; Thalamo.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cerebral Cortex / pathology
  • Corpus Striatum / pathology
  • Humans
  • Neural Pathways / pathology
  • Neurons / pathology
  • Parkinson Disease* / pathology
  • Thalamus* / pathology