Clinical and serologic responses to acellular pertussis vaccine in infants and young children

Am J Dis Child. 1987 Sep;141(9):949-53. doi: 10.1001/archpedi.1987.04460090026016.


We administered diphtheria, tetanus, and pertussis (DTP) vaccine containing acellular (lymphocytosis promoting factor and filamentous hemagglutinin) pertussis vaccine to three groups of 20 children each (4 to 6 years, 17 to 21 months, and 5 to 9 months of age). All the children tolerated the vaccine well; no reactions occurred that contraindicated further immunization. Older children had significantly more local (redness or swelling) and systemic (fever or fretfulness) reactions than younger children. Eighty percent to 90% of the children in the two older age groups had fourfold or greater increases in antibody titers to DTP antigens one month after vaccination. The postvaccine concentrations of antibody to tetanus and diphtheria were greater than 0.01 IU/mL in all children. Serologic responses to lymphocytosis promoting factor and filamentous hemagglutinin varied with age; significantly more older children than younger children had four-fold or greater increases. Acellular pertussis DTP vaccine was antigenic in young children and was less reactogenic than standard whole cell DTP vaccine according to rates reported in previous studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies / analysis
  • Child, Preschool
  • Diphtheria / immunology
  • Diphtheria Toxoid / administration & dosage
  • Diphtheria Toxoid / adverse effects
  • Diphtheria Toxoid / immunology*
  • Drug Evaluation
  • Drug Therapy, Combination
  • Humans
  • Infant
  • Pertussis Vaccine / administration & dosage
  • Pertussis Vaccine / adverse effects
  • Pertussis Vaccine / immunology*
  • Tetanus / immunology
  • Tetanus Toxoid / administration & dosage
  • Tetanus Toxoid / adverse effects
  • Tetanus Toxoid / immunology*
  • Whooping Cough / immunology


  • Antibodies
  • Diphtheria Toxoid
  • Pertussis Vaccine
  • Tetanus Toxoid