COVID-19 and the cardiovascular system-current knowledge and future perspectives

World J Clin Cases. 2022 Sep 26;10(27):9602-9610. doi: 10.12998/wjcc.v10.i27.9602.


The current coronavirus disease 2019 (COVID-19) pandemic has had devastating impact on populations around the world. The high mortality rates in patients with COVID-19 has been attributed to the influence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), its causative viral agent, on several physiological systems in human body, including the respiratory, cardiovascular, and neurological systems. There is emerging evidence on propensity of this virus to attack cardiovascular system. However, various pathophysiological mechanisms by which SARS-CoV-2 interacts with cardiovascular system and leads to high morbidity and mortality, including cardiovascular complications, are poorly understood. This mini review aims to provide an update on the current knowledge and perspectives on areas of future research.

Keywords: Angiotensin-converting enzyme 2 receptors; COVID-19; Cardiovascular manifestations; Therapies.

Publication types

  • Review