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Meta-Analysis
. 2022 Sep 21:2022:1122994.
doi: 10.1155/2022/1122994. eCollection 2022.

Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma

Guimei Huang  1 , Jiayi Wang  2 , Lei Li  3 , Yuan Gao  3 , Yijie Yan  3
Affiliations
Meta-Analysis

Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma

Guimei Huang et al. Comput Math Methods Med. .

Abstract

Objective: We aimed to explore the effect of blood lipid parameters on the risk of primary open-angle glaucoma (POAG) by meta-analysis.

Methods: The databases of PubMed, Scopus, CNKI, and Wanfang were systematically searched from inception to April 2022, and the relevant research literature was obtained, screened, and analyzed.

Results: A total of 15 studies were included in this meta-analysis, including 11 reporting dyslipidemia and risk of POAG and 5 reporting specific lipid level and risk of POAG. Dyslipidemia increased the risk of POAG with an odd ratio (OR) of 1.25 (95% CI: 1.23, 1.26). Total triglyceride and total cholesterol were not related to the prevalence of POAG, but high-density lipoprotein cholesterol was significantly negatively correlated with the risk of POAG with an OR of 0.96 (95% CI: 0.94, 0.99).

Conclusion: Dyslipidemia is a risk factor for POAG. Given the small sample size and significant interstudy heterogeneity, additional studies are needed to establish this conclusion.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Literature screening flowchart.
Figure 2
Figure 2
Forest chart reporting the study on the relationship between dyslipidemia and the risk of POAG.
Figure 3
Figure 3
Forest map reporting the odds ratio for POAG risk by TG level.
Figure 4
Figure 4
Forest map reporting the study on the association between total cholesterol and POAG risk.
Figure 5
Figure 5
Forest map reporting the study on the association between HDLC and POAG risk.
See this image and copyright information in PMC

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