Neutrophil extracellular traps in fungal infections: A seesaw battle in hosts

Front Immunol. 2022 Sep 14;13:977493. doi: 10.3389/fimmu.2022.977493. eCollection 2022.


Fungal infections are a growing health care challenge. Neutrophils play a key role in defense against fungal infections. There are many effective ways for neutrophils to eliminate fungal invaders, such as phagocytosis, oxidative bursts, and the formation of extracellular traps. This process has received considerable attention and has made rapid progress since neutrophil extracellular traps (NETs) formation was described. Here, we describe the formation, induction, and function of NETs, as well as fungal strategies against NETs hunting. We highlight the effects of NETs on common fungal pathogens and how these pathogens survive.

Keywords: Aspergillus; Candida; fungal infection; immunology; neutrophil; neutrophil extracellular traps.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Extracellular Traps*
  • Humans
  • Mycoses*
  • Neutrophils
  • Phagocytosis