Bilateral Corneal Neurotization for Ramos-Arroyo Syndrome and Developmental Neurotrophic Keratopathy: Case Report and Literature Review

Cornea. 2023 Mar 1;42(3):369-371. doi: 10.1097/ICO.0000000000003143. Epub 2022 Sep 29.

Abstract

Purpose: The purpose of this study was to report the use of bilateral corneal neurotization for neurotrophic keratitis in the setting of Ramos-Arroyo syndrome.

Methods: The case report and surgical technique are described in detail in this article, as well as a review of the literature on corneal neurotization for congenital corneal anesthesia.

Results: We report a 17-year-old patient who underwent bilateral corneal neurotization for neurotrophic keratitis secondary to corneal anesthesia in Ramos-Arroyo syndrome. Corneal neurotization was performed with great auricular nerve transfers extended by sural nerve autografts.

Conclusions: We present the treatment of neurotrophic keratopathy with corneal neurotization in a patient with Ramos-Arroyo syndrome. We describe how bilateral corneal neurotization using the great auricular nerve technique is a safe and effective procedure for patients with congenital/developmental corneal anesthesia.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adolescent
  • Cornea / innervation
  • Cornea / surgery
  • Corneal Diseases* / surgery
  • Corneal Dystrophies, Hereditary* / surgery
  • Humans
  • Keratitis* / diagnosis
  • Keratitis* / surgery
  • Nerve Transfer* / methods
  • Trigeminal Nerve Diseases* / surgery

Supplementary concepts

  • Ramos Arroyo Clark syndrome