Dietary sugar lowers immunity and microbiota that protect against metabolic disease

Cell Metab. 2022 Oct 4;34(10):1422-1424. doi: 10.1016/j.cmet.2022.09.006.


Diet influences intestinal microbiota, inflammation, and metabolism. Kawano et al. show that dietary sugar engaged upper gut innate lymphoid cells to replace segmented filamentous bacteria with a pathobiont. Added sugar worsened early metabolic disease by lowering protective Th17 immunity, thereby promoting intestinal lipid absorption and obesity in high-fat-diet-fed mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Diet, High-Fat / adverse effects
  • Dietary Sugars
  • Immunity, Innate
  • Lipids
  • Lymphocytes
  • Metabolic Diseases* / prevention & control
  • Mice
  • Mice, Inbred C57BL
  • Microbiota*


  • Dietary Sugars
  • Lipids