Expression of the c-myc gene in human gastrointestinal malignancies

Biochem Biophys Res Commun. 1987 Jul 31;146(2):699-704. doi: 10.1016/0006-291x(87)90585-7.

Abstract

We have examined the level of the c-myc transcript in 6 esophageal, 16 gastric, 19 colorectal and 1 anal cancer tissue samples; these included four lymph nodes and six hepatic metastases obtained surgically. The esophageal cancer tissues were without an increase of the c-myc transcript, some of the gastric cancer samples showed a two to three fold increase and most of the colorectal and the one anal cancer samples showed a two to ten fold increase when compared with a normal mucosal layer. Therefore, the level of the c-myc transcript in human gastrointestinal malignancies shows organ dependency. Local, lymphatic, and hepatic metastases showed little difference in the level of c-myc mRNA from that of the primary tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics
  • Anus Neoplasms / genetics
  • Colonic Neoplasms / genetics
  • Esophageal Neoplasms / genetics
  • Gastrointestinal Neoplasms / genetics*
  • Gene Expression Regulation*
  • Humans
  • Liver Neoplasms / secondary
  • Lymphatic Metastasis
  • Oncogenes*
  • RNA, Messenger / metabolism
  • Rectal Neoplasms / genetics
  • Stomach Neoplasms / genetics
  • Transcription, Genetic

Substances

  • Actins
  • RNA, Messenger