A perturbed network in neurodegeneration

Science. 2022 Oct 7;378(6615):28-29. doi: 10.1126/science.ade4210. Epub 2022 Oct 6.

Authors

Jean-Marc Gallo¹, Dieter Edbauer^{2

3

4}

Affiliations

¹ Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
² German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
³ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
⁴ Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians-University Munich, Munich, Germany.

PMID: 36201587
DOI: 10.1126/science.ade4210

Abstract

Three proteins act in concert to cause neuronal pathology.

Publication types

Comment

MeSH terms

Amyotrophic Lateral Sclerosis* / genetics
Amyotrophic Lateral Sclerosis* / metabolism
Animals
C9orf72 Protein / genetics
C9orf72 Protein / metabolism
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Frontotemporal Dementia* / genetics
Frontotemporal Dementia* / metabolism
Humans
Mice
Neurons* / metabolism
Protein Serine-Threonine Kinases* / genetics
Protein Serine-Threonine Kinases* / metabolism

Substances

C9orf72 Protein
DNA-Binding Proteins
TARDBP protein, human
Tbk1 protein, mouse
Protein Serine-Threonine Kinases