Endothelial-to-mesenchymal transition in multiple sclerosis: Good cells gone bad

Gabrielle M Mey; Tara M DeSilva

doi:10.1016/j.neuron.2022.09.017

Endothelial-to-mesenchymal transition in multiple sclerosis: Good cells gone bad

Neuron. 2022 Oct 5;110(19):3053-3055. doi: 10.1016/j.neuron.2022.09.017.

Authors

Gabrielle M Mey¹, Tara M DeSilva²

Affiliations

¹ Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve University, Cleveland, OH, USA.
² Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and Case Western Reserve University, Cleveland, OH, USA. Electronic address: desilvt@ccf.org.

PMID: 36202086
DOI: 10.1016/j.neuron.2022.09.017

Abstract

In cancer and cardiovascular disease, endothelial cells can transform into mesenchymal cells (EndoMT), affecting disease onset and progression. In this issue of Neuron, Sun et al. (2022) demonstrate how EndoMT triggers breakdown of the blood-CNS barrier in the pathogenesis of multiple sclerosis.

Publication types

Comment

MeSH terms

Cells, Cultured
Endothelial Cells* / metabolism
Endothelium
Epithelial-Mesenchymal Transition
Humans
Multiple Sclerosis* / metabolism