Triclosan in paired-maternal and cord blood, and their relationships with congenital heart disease of baby

Yu-Ling Luan; Yan-Qiu Ou; Xiao-Qing Liu; Shao Lin; Ying Guo

doi:10.1016/j.scitotenv.2022.159205

Triclosan in paired-maternal and cord blood, and their relationships with congenital heart disease of baby

Sci Total Environ. 2023 Jan 20;857(Pt 1):159205. doi: 10.1016/j.scitotenv.2022.159205. Epub 2022 Oct 4.

Authors

Yu-Ling Luan¹, Yan-Qiu Ou², Xiao-Qing Liu³, Shao Lin⁴, Ying Guo⁵

Affiliations

¹ Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, China.
² Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510632, China. Electronic address: ouyanqiu@gdph.org.cn.
³ Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510632, China.
⁴ Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, University Place, Rensselaer, NY 12144, United States.
⁵ Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, China. Electronic address: yingguo2004@jnu.edu.cn.

PMID: 36202352
DOI: 10.1016/j.scitotenv.2022.159205

Abstract

Prenatal triclosan (TCS) exposure has been reported to be associated with various birth outcomes and thyroid function, while the study of TCS exposure for congenital heart disease (CHD) patients is limited. In the present study, paired mother-fetus blood samples from CHD and healthy participants were collected to measure TCS exposure levels, and then check their relationship. Coupled with the concentrations of thyroid function biomarkers [free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), and thyroid antibodies (TgAb)] in maternal blood, we aimed to investigate whether the hormone-disrupting properties of TCS will affect its association with CHD. Our results indicated that the maternal TCS concentrations in the CHD group (median 0.31 ng/mL) were significantly lower than those in the control group (0.48 ng/mL, Mann Whitney U test, p = 0.01). Higher interquartile of TCS levels in maternal blood was associated with decrease odds of CHD (adjusted OR = 0.61, 95%CI: 0.41-0.91, p = 0.02). Maternal blood TCS higher than the cut-off value (25th quantile, 0.17 ng/mL) was significantly negatively associated with CHD risk (adjusted OR = 0.24, 95%CI: 0.09-0.62, p < 0.01). Besides, none of the thyroid biomarkers were significantly associated with maternal TCS exposure. However, maternal FT4 concentrations were positively correlated with TCS transplacental transfer rate and cord blood TCS levels (general linear regression, both p < 0.01). The results of molecular docking and dynamics simulation suggested that these correlations might be related to the transthyretin, a thyroid hormone-binding protein involved in the placental thyroid hormone transport system. Overall, our findings indicated that at normal exposure levels, the increase of maternal blood TCS concentration may have an inverse association with CHD, which merits further investigation.

Keywords: Congenital heart disease; Molecular docking; Prenatal exposure; Thyroid hormone; Transplacental transfer; Triclosan.

MeSH terms

Female
Fetal Blood / chemistry
Heart Defects, Congenital* / chemically induced
Humans
Maternal Exposure
Molecular Docking Simulation
Placenta / chemistry
Pregnancy
Thyrotropin
Thyroxine
Triclosan* / toxicity

Substances

Triclosan
Thyrotropin
Thyroxine