Malignant pleural mesothelioma in situ

Interact Cardiovasc Thorac Surg. 2022 Oct 10;35(5):ivac255. doi: 10.1093/icvts/ivac255.


Although the diagnosis of malignant pleural mesothelioma at an in situ stage was traditionally challenging, it is now possible owing to advances in molecular biological methods such as P16 fluorescence in situ hybridization or BRCA1-associated protein 1 immunohistochemistry. Here, we report the first case, to our knowledge, of total parietal pleurectomy for mesothelioma in situ. Future follow-up and accumulation of cases are necessary to determine whether total parietal pleurectomy could be applied as a treatment for mesothelioma in situ or not.

Keywords: In situ; Malignant pleural mesothelioma; Pleurectomy.

MeSH terms

  • Humans
  • In Situ Hybridization, Fluorescence
  • Lung Neoplasms* / diagnostic imaging
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / surgery
  • Mesothelioma* / diagnostic imaging
  • Mesothelioma* / surgery
  • Mesothelioma, Malignant*
  • Pleural Neoplasms* / diagnostic imaging
  • Pleural Neoplasms* / surgery