Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world

Jinmiao Lu; Xunjie Zhang; Hong Xu; Zhiping Li

doi:10.3389/fped.2022.888686

Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world

Front Pediatr. 2022 Sep 23:10:888686. doi: 10.3389/fped.2022.888686. eCollection 2022.

Authors

Jinmiao Lu¹, Xunjie Zhang¹, Hong Xu², Zhiping Li²

Affiliations

¹ Department of Clinical Pharmacy, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
² Department of Nephrology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

Abstract

Objectives: The hepatitis B vaccine comprises hepatitis B surface antigen (HBsAg) produced by transgenic yeast cells. There are few serious adverse events (SAE) reports after Hepatitis B vaccination.

Methods: The authors searched the Chinese legal documents database for all SAE with Hepatitis B vaccination from January 2010 to January 2022.

Results: All seven patients received yeast-derived recombinant hepatitis B vaccine. Three cases of myocarditis (death), 2 cases of interstitial pneumonia (death), and 2 cases of encephalitis. The mean time of onset of SAE was 8.3 ± 4.3 h after vaccination.

Conclusion: The mechanism of vaccine-induced myocarditis may come from immune protein reactions. Based on the experience of Hepatitis B vaccine adverse events, we present new insights into the mechanism of myocarditis caused by the COVID-19 vaccine.

Keywords: COVID-19; hepatitis B; myocarditis; safety; vaccine.