Analysis of diastolic left ventricular wall shear stress in normal people of different age groups

Liping Dong; Hairu Li; Xiangli Xu; Min Ren; Weidong Yu; Wenkun Bai; Di Sun; Jiawei Tian

doi:10.3389/fcvm.2022.953384

Analysis of diastolic left ventricular wall shear stress in normal people of different age groups

Front Cardiovasc Med. 2022 Sep 23:9:953384. doi: 10.3389/fcvm.2022.953384. eCollection 2022.

Authors

Liping Dong¹, Hairu Li¹, Xiangli Xu², Min Ren³, Weidong Yu¹, Wenkun Bai⁴, Di Sun⁴, Jiawei Tian¹

Affiliations

¹ Department of Ultrasound Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.
² Department of Ultrasound Medicine, The Second Hospital of Harbin, Harbin, China.
³ Department of Ultrasound Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
⁴ Department of Ultrasound Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Background: Diastolic wall shear stress (WSS), assessed by using vector flow mapping (VFM), is the result of the interaction between the blood flow and the ventricular wall. This study aimed to evaluate the trend of left ventricular (LV) WSS in normal subjects.

Methods and results: A total of 371 healthy volunteers were recruited and divided into four age groups (group I: 18-30 years; group II: 31-43 years; group III: 44-56 years; group IV: 57-70 years). LV WSS of different age groups was measured at each diastolic phase (P1: isovolumic diastolic period, P2: rapid filling period, P3: slow filling period, and P4:atrial contraction period) to evaluate the change trend of LV WSS. In each age group, LV WSS coincided with a trend of increasing-decreasing-increasing during P1-P4 (P < 0.05). Besides, among groups I, II, III, and IV, WSS of anterolateral, inferoseptal, and anteroseptal in P1 and WSS of inferolateral, inferoseptal, and anteroseptal in P4 all showed an increasing trend with age (P < 0.05). Regarding sex differences, women had greater diastolic WSS compared to men (P < 0.05).

Conclusion: LV WSS showed a regular variation and had specific age- and sex-related patterns in different diastolic phases.

Keywords: echocardiography; hemodynamics; left ventricle (LV); vector flow mapping; wall shear stress.