Topical cyclosporine hydrogel preparation: A new therapeutic option in the treatment of nail psoriasis

Dermatol Ther. 2022 Dec;35(12):e15917. doi: 10.1111/dth.15917. Epub 2022 Oct 17.


Nail psoriasis is a chronic nail disorder that commonly affects psoriatic patients causing severe distress despite the limited body surface area. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies, and among different systemic agents responses are unpredictable. We carried out a prospective study in order to analyze the effectiveness and tolerability of topical cyclosporine hydrogel ointment in nail psoriasis. Three patients, for a total of 44 nails, were treated with topical cyclosporine hydrogel ointment. All nails were evaluated, before starting the treatment, every 28 days and after 12 weeks of therapy, by the same dermatologists, through clinical and onychoscopic evaluations. The patients were also asked to assess on the compliance with product use. Complete response (CR) was observed in 2 of 3 patients; a partial response (PR) was observed in the other patient. Overall, 24 of 44 nails had CR and 20 had a PR. Cyclosporine hydrogel ointment has shown efficacy and safety in the treatment of nail psoriasis. The product has also been shown to be stable in composition, easy to apply and not discomfortable for the patient.

Keywords: cyclosporine; hydrogel ointment; nail psoriasis; topical therapy; treatment.

MeSH terms

  • Cyclosporine
  • Dermatologic Agents*
  • Humans
  • Hydrogels / therapeutic use
  • Nail Diseases* / diagnosis
  • Nail Diseases* / drug therapy
  • Nail Diseases* / etiology
  • Ointments / therapeutic use
  • Prospective Studies
  • Psoriasis* / complications
  • Psoriasis* / diagnosis
  • Psoriasis* / drug therapy


  • Cyclosporine
  • Dermatologic Agents
  • Ointments
  • Hydrogels