A case of ulcerative colitis-related postoperative enteritis treated with granulocyte and monocyte apheresis

Clin J Gastroenterol. 2023 Feb;16(1):43-47. doi: 10.1007/s12328-022-01716-3. Epub 2022 Oct 10.


A 46-year-old man, receiving continuous steroid therapy for refractory ulcerative colitis with an insufficient response to anti-tumor necrosis factor-α therapy, presented with left buttock pain. He was diagnosed with steroidal left femoral head necrosis, and total proctocolectomy with permanent ileostomy was performed. At 6 months postoperatively, the patient developed general fatigue, abdominal pain, and severe ileostomy diarrhea. Computed tomography revealed continuous intestinal edema from the descending duodenal leg to the upper jejunum. Gastrointestinal endoscopy revealed deep ulcers, coarse mucosa, and duodenal erosion. Based on clinical progress, findings, and pathology, the patient was diagnosed with ulcerative colitis-related postoperative enteritis. Although 5-aminosalicylic acid treatment was initiated, his symptoms persisted, bloody diarrhea from colostomy was observed. Subsequently, granulocyte and monocyte apheresis treatment was added. Symptoms and endoscopic findings improved with granulocyte and monocyte apheresis. Azathioprine was introduced as maintenance therapy, and no sign of recurrence was observed. Although ulcerative colitis-related postoperative enteritis has no definitive treatment, granulocyte and monocyte apheresis may be considered for initial treatment.

Keywords: Granulocyte and monocyte apheresis; Leucine-rich alpha 2 glycoprotein; Ulcerative colitis-related postoperative enteritis.

Publication types

  • Case Reports

MeSH terms

  • Blood Component Removal*
  • Colitis, Ulcerative* / diagnosis
  • Enteritis*
  • Granulocytes / pathology
  • Humans
  • Leukapheresis / methods
  • Male
  • Middle Aged
  • Monocytes / pathology
  • Steroids
  • Treatment Outcome


  • Steroids