Non-mosaic isodicentric X-chromosome in a patient with secondary amenorrhea

Clin Genet. 1987 Jul;32(1):20-3. doi: 10.1111/j.1399-0004.1987.tb03317.x.

Abstract

An isodicentric X-chromosome idic(X) (pter----q26.1::q26.1----pter) was found in lymphocytes and ovarian tissue of a 40-year-old female patient with secondary amenorrhea. No mosaicism was observed. The phenotype-karyotype correlation of our case and of previously described non-mosaic cases of idic(X) (q::q) with different breakpoints is discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amenorrhea / etiology*
  • Amenorrhea / pathology
  • Female
  • Gonadal Dysgenesis / complications
  • Gonadal Dysgenesis / genetics*
  • Gonadal Dysgenesis / pathology
  • Humans
  • Lymphocytes / ultrastructure
  • Ovary / ultrastructure
  • Sex Chromosome Aberrations / genetics*
  • Sex Chromosome Aberrations / pathology
  • X Chromosome / ultrastructure*