Getting the guts to expand stroke treatment: The potential for microbiome targeted therapies

Molly Monsour; Davide M Croci; Siviero Agazzi; Cesario V Borlongan

doi:10.1111/cns.13988

Getting the guts to expand stroke treatment: The potential for microbiome targeted therapies

CNS Neurosci Ther. 2023 Jun;29 Suppl 1(Suppl 1):213-219. doi: 10.1111/cns.13988. Epub 2022 Oct 10.

Authors

Molly Monsour¹, Davide M Croci², Siviero Agazzi², Cesario V Borlongan³

Affiliations

¹ University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
² Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
³ Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.

Abstract

Aims: This review focuses on the recent literature regarding the role of the gut-brain axis (GBA) following ischemic stroke.

Discussion: Stroke is the 5th leading cause of death and disability in the United States; however, few therapies have been developed to improve prognoses. There is a plethora of evidence suggesting peripheral inflammatory responses play a large role in the pathogenesis of stroke. Additionally, hyperglycemic conditions may play a significant role in worsening stroke outcomes due to microbiome dysbiosis.

Conclusion: Recent research has illuminated the vital role of the GBA in propagating poor clinical outcomes, such as hemorrhagic transformation, following ischemic stroke. Considering this detrimental consequence of stroke, and the apparent role of the GBA role, future therapeutics should aim to mitigate this peripheral contribution to stroke complications.

Keywords: gut-brain axis; hemorrhagic transformation; ischemic stroke; microbiota; stem cells.

Publication types

Review

MeSH terms

Gastrointestinal Microbiome* / physiology
Humans
Ischemic Stroke* / complications
Microbiota*
Stroke* / complications
Stroke* / therapy