Cold exposure as anti-cancer therapy

Cancer Cell. 2022 Oct 10;40(10):1092-1094. doi: 10.1016/j.ccell.2022.09.008.


Seki et al. report in Nature that increasing glucose catabolism in brown adipose tissue by cold exposure lowers blood glucose and insulin tolerance. This systemic effect on body metabolism decreases glucose catabolism in tumors and arrests tumor progression, offering a novel alternative approach for metabolism-based cancer therapy.

Publication types

  • Comment

MeSH terms

  • Adipose Tissue, Brown / metabolism
  • Blood Glucose* / metabolism
  • Energy Metabolism
  • Glucose / metabolism
  • Humans
  • Insulins* / metabolism


  • Blood Glucose
  • Insulins
  • Glucose