Primary bronchial schwannoma: A case report

Medicine (Baltimore). 2022 Oct 7;101(40):e31062. doi: 10.1097/MD.0000000000031062.


Rationale: Bronchial schwannomas are extremely rare among the benign tracheobronchial tumors and little are known about its epidemiology and optimal clinical management. Here, we report a case of bronchial schwannoma in a young Japanese man and clinical implications about epidemiology, symptom, diagnosis, and treatment of bronchial schwannoma.

Patients concern: A 37-year-old man visited our department with a nodule incidentally found on his chest radiograph during a routine medical checkup.

Diagnosis: The tumor was diagnosed as a bronchial schwannoma after pathological evaluation. Microscopically, the tumor consisted of spindle cell proliferation characterized by an alternating highly ordered cellular Antoni A component with occasional nuclear palisading and a loose myxoid Antoni B component. Tumor cells were immunoreactive for S100 but not for smooth muscle actin or KIT.

Interventions: A video-assisted right middle and lower bilobectomy was performed.

Outcome: He remains under observation without recurrence.

Lessons: In our review, many reports have come from Asian countries. Bronchial schwannoma can occur within a wide range of age groups and in both men and women. No difference in incidence was observed between right and left bronchial tree. Bronchial schwannoma is sometimes difficult to differentiate from malignant diseases. We should include bronchial schwannoma as one of the differential diagnoses of primary bronchial tumors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Actins
  • Adult
  • Bronchial Neoplasms* / diagnostic imaging
  • Bronchial Neoplasms* / surgery
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Neurilemmoma* / diagnosis
  • Neurilemmoma* / pathology
  • Neurilemmoma* / surgery
  • Pneumonectomy


  • Actins