Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner

ASN Neuro. 2022 Jan-Dec:14:17590914221131446. doi: 10.1177/17590914221131446.


Diabetic human and murine retinas revealed pronounced microglial morphological activation and vascular abnormalities associated with inflammation. Pharmacological fibrinogen depletion using ancrod dampened microglial morphology alterations, resolved fibrinogen accumulation, rescued axonal integrity, and reduced inflammation in the diabetic murine retina.

Keywords: ancrod; diabetic retinopathy; fibrinogen; inflammation; microglia; visual acuity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Ancrod*
  • Animals
  • CX3C Chemokine Receptor 1 / genetics
  • Fibrinogen
  • Humans
  • Inflammation / drug therapy
  • Mice
  • Microglia
  • Retina* / physiology


  • CX3C Chemokine Receptor 1
  • CX3CR1 protein, human
  • Cx3cr1 protein, mouse
  • Fibrinogen
  • Ancrod