New High Yield Cu(I) Assisted 123I Radioiodination of 15(p-I-phenyl)-9-methyl Pentadecanoic Acid, a Potential Myocardial Tracer

Eur J Nucl Med. 1987;13(3):159-60. doi: 10.1007/BF00289030.

Abstract

A new high yield 123I radioiodination (97%), based on the Cu(I) assisted isotopic exchange in an ethanol water mixture, of 15(p-I-phenyl)-9 methyl pentadecanoic acid, a potential myocardial tracer, is proposed. The method allows a true kit preparation of radioiodinated phenyl fatty acids for a substrate concentration of +/- 10(-6) moles. High specific activities (greater than 0.1 mCi/micrograms) can be obtained when coupling the labelling method to HPLC purification with an overall radiochemical yield of 75%.

MeSH terms

  • Fatty Acids*
  • Heart Diseases / diagnostic imaging*
  • Humans
  • Iodine Radioisotopes*
  • Iodobenzenes*
  • Radiochemistry
  • Radionuclide Imaging

Substances

  • Fatty Acids
  • Iodine Radioisotopes
  • Iodobenzenes
  • iodofiltic acid