Demographic profile, management, and survival of primary Gastrointestinal Kaposi Sarcoma: A USA Nationwide SEER-based study

Niraj James Shah; Mark M Aloysius; Eldrin Bhanat; Shweta Gupta; John Savio; Ganesh Aswath; David C Schafer; Hemant Goyal

doi:10.1016/j.canep.2022.102277

Demographic profile, management, and survival of primary Gastrointestinal Kaposi Sarcoma: A USA Nationwide SEER-based study

Cancer Epidemiol. 2022 Dec:81:102277. doi: 10.1016/j.canep.2022.102277. Epub 2022 Oct 10.

Authors

Niraj James Shah¹, Mark M Aloysius², Eldrin Bhanat³, Shweta Gupta⁴, John Savio⁵, Ganesh Aswath⁶, David C Schafer⁷, Hemant Goyal⁸

Affiliations

¹ Department of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. Electronic address: nirajjames@gmail.com.
² Department of Internal Medicine, The Wright Center for Graduate Medical Education, 501S. Washington Avenue, Scranton, PA 18505, USA; Geisinger Commonwealth School of Medicine, 525, Pine Street, Scranton, PA 18510, USA. Electronic address: madhoka@thewrightcenter.org.
³ Department of Surgery, Division of Orthopedics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. Electronic address: ebhanat@umc.edu.
⁴ Division of Hematology-Oncology, John H Stroger Jr Hospital of Cook County, 1950 W Polk St, Chicago, IL 60612, USA. Electronic address: sgupta@cookcountyhhs.org.
⁵ Division Chief Gastroenterology, Upstate University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA. Electronic address: johns@upstate.edu.
⁶ Division of Gastroenterology, Upstate University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA. Electronic address: ga.aswath@gmail.com.
⁷ Department of Medicine, Division of Digestive Diseases, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. Electronic address: dschaefer@umc.edu.
⁸ Division of Gastroenterology, Hepatology and Nutrition, University of Texas, 6431, Fannin, Houston, TX 77030, USA; Mercer University School of Medicine Macon, GA 31207, USA. Electronic address: doc.hemant@yahoo.com.

PMID: 36228566
DOI: 10.1016/j.canep.2022.102277

Abstract

Kaposi Sarcoma (KS) is a Human Herpes Virus-8 (HHV-8) associated angio-proliferative disorder commonly seen in patients with HIV. It most commonly involves the skin as classic purple lesions but occasionally involves the gastrointestinal (GI) tract. To date, published data is scarce on primary GI KS. Using a national database, this study analyzes the incidence, demographics, and survival of primary GI KS. We conducted a retrospective analysis (1975-2019) on biopsy-proven primary GI KS cases from 17 registries from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 685 patients with GI KS were identified. Female gender, Non-Hispanic Asian or Pacific Islander (NHAPI), married marital status, and large bowel site-specific primary KS to have better overall survival. Luminal gastrointestinal KS was more frequent (84.96%) than solid organ involvement (3.07% of all cases). This study is the most extensive population-based study about the epidemiological and survival data of patients with primary GI KS, revealing GI KS to be a young male disease with best outcomes in the large bowel and anal canal KS while inferior outcomes in extraintestinal GI KS.

Keywords: Chemotherapy; Ethnicity; Gastrointestinal Kaposi sarcoma; Primary Kaposi sarcoma; Radiation therapy; Socioeconomic factors; Survival.