Advances in Multimodality Imaging in Cardio-Oncology: JACC State-of-the-Art Review

J Am Coll Cardiol. 2022 Oct 18;80(16):1560-1578. doi: 10.1016/j.jacc.2022.08.743.


The population of patients with cancer is rapidly expanding, and the diagnosis and monitoring of cardiovascular complications greatly rely on imaging. Numerous advances in the field of cardio-oncology and imaging have occurred in recent years. This review presents updated and practical approaches for multimodality cardiovascular imaging in the cardio-oncology patient and provides recommendations for imaging to detect the myriad of adverse cardiovascular effects associated with antineoplastic therapy, such as cardiomyopathy, atherosclerosis, vascular toxicity, myocarditis, valve disease, and cardiac masses. Uniquely, we address the role of cardiovascular imaging in patients with pre-existing cardiomyopathy, pregnant patients, long-term survivors, and populations with limited resources. We also address future avenues of investigation and opportunities for artificial intelligence applications in cardio-oncology imaging. This review provides a uniform practical approach to cardiovascular imaging for patients with cancer.

Keywords: cardio-oncology; imaging; multimodality.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents* / adverse effects
  • Artificial Intelligence
  • Cardiovascular Diseases* / complications
  • Cardiovascular Diseases* / diagnostic imaging
  • Drug-Related Side Effects and Adverse Reactions*
  • Heart Diseases* / diagnosis
  • Humans
  • Medical Oncology
  • Neoplasms* / complications
  • Neoplasms* / diagnostic imaging
  • Neoplasms* / drug therapy


  • Antineoplastic Agents