SIPA1 Regulates LINC01615 to Promote Metastasis in Triple-Negative Breast Cancer

Yuan Xiang; Lingyun Feng; Hui Liu; Yuhuan Liu; Jiapeng Li; Li Su; Xinghua Liao

doi:10.3390/cancers14194815

SIPA1 Regulates LINC01615 to Promote Metastasis in Triple-Negative Breast Cancer

Cancers (Basel). 2022 Oct 1;14(19):4815. doi: 10.3390/cancers14194815.

Authors

Yuan Xiang¹, Lingyun Feng², Hui Liu³, Yuhuan Liu², Jiapeng Li³, Li Su², Xinghua Liao³

Affiliations

¹ Department of Medical Laboratory, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
² Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430081, China.
³ Institute of Biology and Medicine, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430081, China.

Abstract

Long non-coding RNAs (lncRNAs) are reported to play an important regulatory effect in carcinogenesis and malignancy. We found by high-throughput sequencing that LINC01615 is upregulated in breast cancer patients and reduces patients' overall survival. In vivo and in vitro experiments, we clarified that overexpression of LINC01615 can promote breast cancer cell metastasis ability. The expression of LINC01615 is regulated by the transcriptional activator SIPA1, thereby promoting carcinogenesis in breast cancer cells. Our research clarified that LINC01615 can act as an oncogenic factor in promoting the development of breast cancer.

Keywords: LINC01615; MMP9; SIPA1; breast cancer.

Grants and funding

This work was financially supported by the MOST-Key Program for International S&T Cooperation Projects of China (2017YFE0129100), National Natural Science Foundation of China (81872154) and Hubei Natural Science Foundation (2021CFB230 and 2017CFB537), and Educational Commission of Hubei (B2020001), Hubei Province Health and Family Planning Scientific Research Project (WJ2021Q051, WJ2019M255), Frontier project of applied basic research in Wuhan (2020020601012250), Project of Wuhan Municipal Health Commission (WX21Q49).