Short-Term Associations between Size-Fractioned Particles and Cardiopulmonary Function in COPD Patients: A Panel Study in Shanghai, China, during 2014-2021

Int J Environ Res Public Health. 2022 Sep 30;19(19):12473. doi: 10.3390/ijerph191912473.


It remains unknown which size fractions dominate the adverse cardiopulmonary effects of particulate matter (PM). Therefore, this study aimed to explore the differential associations between size-fractioned particle number concentrations (PNCs) and cardiopulmonary function measures, including the forced expiratory volume in one second (FEV1), the forced vital capacity (FVC), and the left ventricular ejection fraction (LVEF). We conducted a panel study among 211 patients with chronic obstructive pulmonary disease (COPD) in Shanghai, China, between January 2014 and December 2021. We applied linear mixed-effect models to determine the associations between cardiopulmonary function measures and PNCs ranging from 0.01 to 10 μm in diameter. Generally, only particles <1 μm showed significant associations, i.e., ultrafine particles (UFPs, <0.1 μm) for FVC and particles ranging from 0.1 to 1 µm for FEV1 and LVEF. An interquartile range (IQR) increment in UFP was associated with decreases of 78.4 mL in FVC. PNC0.1-0.3 and PNC0.3-1 corresponded to the strongest effects on FEV1 (119.5 mL) and LVEF (1.5%) per IQR increment. Particles <1 µm might dominate the cardiopulmonary toxicity of PM, but UFPs might not always have the strongest effect. Tailored regulations towards particles <1 µm should be intensified to reduce PM pollution and protect vulnerable populations.

Keywords: COPD; cardiopulmonary function; panel study; size-fractioned particles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air Pollutants* / analysis
  • Air Pollutants* / toxicity
  • Air Pollution* / adverse effects
  • Air Pollution* / analysis
  • China / epidemiology
  • Environmental Exposure / adverse effects
  • Humans
  • Particle Size
  • Particulate Matter / analysis
  • Pulmonary Disease, Chronic Obstructive*
  • Stroke Volume
  • Ventricular Function, Left


  • Air Pollutants
  • Particulate Matter

Grant support

This research was funded by the Collaborating Program of Fudan-Minhang Academic Health System (2020FM10) and the Shanghai Committee of Science and Technology (21TQ015).