An Atlas of Thyroid Hormone Receptors' Target Genes in Mouse Tissues

Int J Mol Sci. 2022 Sep 28;23(19):11444. doi: 10.3390/ijms231911444.


We gathered available RNA-seq and ChIP-seq data in a single database to better characterize the target genes of thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of thyroid hormone (T3). Additionally, it is an easy-to-use and convenient tool to obtain information on specific genes regarding T3 regulation or to extract large gene lists of interest according to the users' criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on T3, its receptors, modes of action, targets and roles, which may benefit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes where transcription is upregulated by chromatin-bound nuclear receptors. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of the hormonal response.

Keywords: ChIP-seq; RNA-seq; atlas; target genes; thyroid hormone receptors.

MeSH terms

  • Animals
  • Chromatin / genetics
  • Mice
  • Receptors, Thyroid Hormone* / genetics
  • Receptors, Thyroid Hormone* / metabolism
  • Thyroid Hormones* / genetics
  • Thyroid Hormones* / metabolism
  • Triiodothyronine / metabolism


  • Chromatin
  • Receptors, Thyroid Hormone
  • Thyroid Hormones
  • Triiodothyronine