Multiorgan neutrophilic inflammation in a Border Collie with "trapped" neutrophil syndrome

J Vet Intern Med. 2022 Nov;36(6):2170-2176. doi: 10.1111/jvim.16567. Epub 2022 Oct 14.


Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil syndrome based on clinical features, blood and bone marrow evaluation, and presence of the associated homozygous mutation. Results from flow cytometric and storage studies suggested lower neutrophil survival time. The dog had substantial neutrophilic inflammation in multiple organs, indicating that neutrophils could leave the marrow and enter tissues, making the term "trapped" neutrophil syndrome a misnomer.

Keywords: Cohen syndrome; VPS13B; bone marrow; ineffective myelopoiesis; neutropenia.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Dog Diseases* / genetics
  • Dogs
  • Inflammation / veterinary
  • Mutation
  • Neutropenia* / veterinary
  • Neutrophils
  • Syndrome

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