Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection

Clin Infect Dis. 2023 Feb 18;76(4):730-733. doi: 10.1093/cid/ciac823.


In the Swiss HIV Cohort Study, 61 of 222 (27%) HIV-suppressed persons with chronic hepatitis B virus (HBV) infection had HBV replication after 2 years on tenofovir, of whom 77% were suppressed thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were predictors of persistent replication.

Keywords: coinfection; hepatitis B virus; human immunodeficiency virus; tenofovir; viral replication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • Coinfection*
  • DNA, Viral
  • HIV
  • HIV Infections*
  • Hepatitis B virus / genetics
  • Hepatitis B*
  • Hepatitis B, Chronic*
  • Humans
  • Tenofovir
  • Viral Load


  • Tenofovir
  • DNA, Viral