Thin-layer chromatographic examination of the degradation of centbucridine in aqueous solutions

J Chromatogr. 1987 Jun 19;396:337-44. doi: 10.1016/s0021-9673(01)94071-3.

Abstract

Centbucridine (9-n-butylamino-1,2,3,4-tetrahydroacridine) is a new potent local anaesthetic. Its degradation in aqueous solutions has been investigated with the help of thin-layer chromatography. Apart from the degradation products 9-amino-1,2,3,4-tetrahydroacridine and 1,2,3,4-tetrahydroacridone, acridone was also found to be present. It is shown that the acridone is produced not through a dehydrogenation reaction but some other unknown pathway.

MeSH terms

  • Aminoacridines / analysis*
  • Anesthetics, Local / analysis*
  • Chromatography, Thin Layer
  • Drug Stability
  • Solutions
  • Spectrophotometry, Ultraviolet
  • Tacrine / analogs & derivatives
  • Tacrine / analysis*

Substances

  • Aminoacridines
  • Anesthetics, Local
  • Solutions
  • Tacrine
  • centbucridine