Life expectancy in multiple sclerosis by EDSS score

Mult Scler Relat Disord. 2022 Dec:68:104219. doi: 10.1016/j.msard.2022.104219. Epub 2022 Oct 5.


The median survival time of newly-diagnosed MS patients without severe disabilities is approximately 30-35 years. The prognosis after the onset of severe disability has not been reported. Based on Harding et al.'s 2018 study of the Southeast Wales MS registry, we calculated life expectancies according to the Expanded Disability Status Scale (EDSS). Upon loss of independent ambulation (EDSS 6-6.5; mean age 51.2) life expectancy was 13.3 additional years. At EDSS 9-9.5 (mean age 70.8) life expectancy was 1.1 additional years. These figures provide an empirical basis for discussions of advanced MS care planning.

Keywords: Expanded disability status scale; Life expectancy; Mortality; Multiple sclerosis.

Publication types

  • Letter

MeSH terms

  • Aged
  • Disability Evaluation
  • Disabled Persons*
  • Humans
  • Life Expectancy
  • Middle Aged
  • Multiple Sclerosis* / diagnosis
  • Registries
  • Wales