Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis

Ageing Res Rev. 2022 Dec:82:101760. doi: 10.1016/j.arr.2022.101760. Epub 2022 Oct 13.


The linguistic and anatomical variability of the logopenic variant of Primary Progressive Aphasia (lv-PPA) as defined by current diagnostic criteria has been the topic of an intense debate. The present review and meta-analysis aims at characterizing the profile of lv-PPA, by a comprehensive analysis of the available literature on the neuropsychological, neuroimaging, electrophysiological, pathological, and genetic features of lv-PPA. We conducted a systematic bibliographic search, leading to the inclusion of 207 papers. Of them, 12 were used for the Anatomical Likelihood Estimation meta-analysis on grey matter revealed by magnetic resonance imaging data. The results suggest that the current guidelines outline a relatively consistent syndrome, characterized by a core set of linguistic and, to a lesser extent, non-linguistic deficits, mirroring the involvement of left temporal and parietal regions typically affected by Alzheimer Disease pathology. Variations of the lv-PPA profile are discussed in terms of heterogeneity of the neuropsychological instruments and the diagnostic criteria adopted.

Keywords: Language; Logopenic variant of Primary Progressive Aphasia; Meta-analysis; Neural biomarkers; Neuropsychology; Primary Progressive Aphasia; Systematic review.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Alzheimer Disease* / pathology
  • Aphasia, Primary Progressive* / diagnosis
  • Aphasia, Primary Progressive* / pathology
  • Aphasia, Primary Progressive* / psychology
  • Cerebral Cortex / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Neuropsychological Tests