Prospective study of scheduled withdrawal from nortriptyline in children and adolescents

J Clin Psychopharmacol. 1987 Aug;7(4):252-4.


Thirty 6- to 16-year-old subjects were gradually tapered from their maintenance dose of nortriptyline while being monitored for withdrawal effects. Five subjects had brief gastrointestinal distress that did not require the administration of an extra dose. The results of this open study suggest that scheduled tapering of nortriptyline will preclude withdrawal symptoms in most pediatric patients.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Depressive Disorder / drug therapy*
  • Female
  • Gastrointestinal Diseases / chemically induced
  • Humans
  • Male
  • Nortriptyline / adverse effects*
  • Nortriptyline / therapeutic use
  • Prospective Studies
  • Substance Withdrawal Syndrome / etiology*


  • Nortriptyline