Genetic profile of sports climbing athletes from three different ethnicities

Mika Saito; Michał Ginszt; Ekaterina A Semenova; Myosotis Massidda; Kinga Huminska-Lisowska; Monika Michałowska-Sawczyn; Hiroki Homma; Paweł Cięszczyk; Takanobu Okamoto; Andrey K Larin; Edward V Generozov; Piotr Majcher; Koichi Nakazato; Ildus I Ahmetov; Naoki Kikuchi

doi:10.5114/biolsport.2022.109958

Genetic profile of sports climbing athletes from three different ethnicities

Biol Sport. 2022 Oct;39(4):913-919. doi: 10.5114/biolsport.2022.109958. Epub 2021 Nov 10.

Authors

Mika Saito¹, Michał Ginszt², Ekaterina A Semenova^{3

4}, Myosotis Massidda^{5

6}, Kinga Huminska-Lisowska⁷, Monika Michałowska-Sawczyn⁷, Hiroki Homma¹, Paweł Cięszczyk⁷, Takanobu Okamoto¹, Andrey K Larin³, Edward V Generozov³, Piotr Majcher², Koichi Nakazato¹, Ildus I Ahmetov^{3

8

9

10}, Naoki Kikuchi¹

Affiliations

¹ Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
² Department of Rehabilitation and Physiotherapy, Medical University of Lublin, Poland.
³ Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
⁴ Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, Kazan, Russia.
⁵ Department of Life and Environmental Sciences, University of Cagliari, Italy.
⁶ Faculty of Medicine and Surgery, Graduate School of Exercise and Sports Sciences, University of Cagliari, Cagliari, Italy.
⁷ Faculty of Physical Education, Gdañsk University of Physical Education and Sport, Gdañsk, Poland.
⁸ Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia.
⁹ Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia.
¹⁰ Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

Abstract

This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the meta-analysis on three cohorts showed that the frequency of XX + RX genotypes in the ACTN3 R577X polymorphism was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities.

Keywords: ACE; ACTN3; CKM; Polymorphism; Sports Climbing; TRHR.