A Theranostic Approach for CAR-T Cell Therapy

Clin Cancer Res. 2022 Dec 15;28(24):5241-5243. doi: 10.1158/1078-0432.CCR-22-2565.


Fibroblast activation protein (FAP) is frequently expressed in the tumor stroma, whereas expression by normal organs is highly restricted. Despite these promising features, FAP-targeted therapies have shown limited success so far. FAP imaging offers new opportunities to select patients for FAP-targeted therapies and monitor tumor response. See related article by Lee et al., p. 5330.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Line, Tumor
  • Cell- and Tissue-Based Therapy
  • Endopeptidases
  • Gelatinases* / genetics
  • Humans
  • Membrane Proteins / metabolism
  • Precision Medicine
  • Receptors, Chimeric Antigen* / metabolism
  • Serine Endopeptidases
  • T-Lymphocytes / metabolism


  • Gelatinases
  • Serine Endopeptidases
  • Receptors, Chimeric Antigen
  • Endopeptidases
  • Membrane Proteins