A case of acute interstitial nephritis induced by flurbiprofen

Jpn J Med. 1987 May;26(2):230-3. doi: 10.2169/internalmedicine1962.26.230.


Recently, acute interstitial nephritis (AIN) presenting nephrotic syndrome and renal failure induced by nonsteroidal anti-inflammatory drug (NSAID) has been recognized with increasing frequency. We described here a 43-year-old woman who developed this type of nephropathy after taking NSAID for rheumatoid arthritis. Flurbiprofen (Froben) was assumed to be a causal drug based on a clinical course and a positive result of lymphocyte transformation test. Withdrawal of flurbiprofen therapy led no sufficient improvement, and high-dose steroid therapy done 15 months after the onset resulted in only a minor improvement. So far as we know, this was the second case of AIN associated with flurbiprofen and the youngest in NSAID-induced AIN with irreversible chronic renal insufficiency.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Acute Kidney Injury / chemically induced
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Rheumatoid / drug therapy
  • Female
  • Flurbiprofen / adverse effects*
  • Humans
  • Nephritis, Interstitial / chemically induced*
  • Propionates / adverse effects*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Propionates
  • Flurbiprofen